منابع مشابه
Binding of aminoglycosides to feces.
Gentamicin and several other basic antibiotics were examined for their ability to adsorb to dog feces. It was found that 44 to 90% of all antibiotics studied were adsorbed to feces depending on the ratio of antibiotic to fecal material. Attempts to extract these antibiotics by acid treatment after adsorption onto feces were only partially successful since large portions of the bound materials w...
متن کاملElectrostatic Interactions in RNA Aminoglycosides Binding
Aminoglycoside antibiotics interact with seemingly unrelated families of RNA molecules. They bind to 16S ribosomal RNA and interfere with the decoding mechanism by distorting the codon-anticodon recognition.1,2 Similar aminoglycosides specifically inhibit self-splicing group I introns3 and the hammerhead ribozyme.4 Recently, these antibiotics have been found to competitively block the binding o...
متن کاملEvaluation of RNA-binding specificity of aminoglycosides with DNA microarrays.
We have developed methods for using DNA array technology to probe the entire transcriptome to determine the RNA-binding specificity of ligands. Two methods were investigated. In the first method, the RNA-binding aminoglycoside antibiotic tobramycin was covalently linked to magnetic beads. The beads were bound to human liver mRNA and washed, and specifically bound RNA was eluted, amplified, and ...
متن کاملComputerized approach to monitoring aminoglycosides.
Aminoglycosides are still used extensively in the treatment of nosocomial infections with Gram-negative bacteria. However, the treatment is associated with several adverse effects. Aminoglycosides monitoring is therefore essential to prevent toxic accumulations and to reach therapeutic concentrations. A computer program, PHARMONITOR, has been developed to optimize aminoglycosides monitoring, re...
متن کاملIntracellular polyamine pools, oligopeptide-binding protein A expression, and resistance to aminoglycosides in Escherichia coli.
The role of intracellular free polyamine (putrescine and spermidine) pools in multiple resistance to aminoglycoside antibiotics was investigated among in vitro selected kanamycin-resistant Escherichia coli J53 mutants expressing diminished oligopeptide-binding protein (OppA) levels and/or defective ornithine decarboxylase (ODC) activity. The results suggest that diminished OppA content, but not...
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ژورنال
عنوان ژورنال: Antimicrobial Agents and Chemotherapy
سال: 1974
ISSN: 0066-4804,1098-6596
DOI: 10.1128/aac.6.4.415